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cn03  (Cytoskeleton Inc)
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Cytoskeleton Inc cn03
Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with <t>CN03</t> (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
Cn03, supplied by Cytoskeleton Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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activity monitoring device  (ActiGraph llc)
90
ActiGraph llc activity monitoring device
Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with <t>CN03</t> (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
Activity Monitoring Device, supplied by ActiGraph llc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/activity monitoring device/product/ActiGraph llc
Average 90 stars, based on 1 article reviews
activity monitoring device - by Bioz Stars, 2026-03
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activity tracking watch  (Garmin Ltd)
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Garmin Ltd activity tracking watch
Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with <t>CN03</t> (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
Activity Tracking Watch, supplied by Garmin Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
activity tracking watch - by Bioz Stars, 2026-03
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wrist-worn actigraph gt9x link activity monitor  (ActiGraph llc)
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ActiGraph llc wrist-worn actigraph gt9x link activity monitor
Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with <t>CN03</t> (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
Wrist Worn Actigraph Gt9x Link Activity Monitor, supplied by ActiGraph llc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/wrist-worn actigraph gt9x link activity monitor/product/ActiGraph llc
Average 90 stars, based on 1 article reviews
wrist-worn actigraph gt9x link activity monitor - by Bioz Stars, 2026-03
90/100 stars
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gt9x link activity monitors  (ActiGraph llc)
90
ActiGraph llc gt9x link activity monitors
Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with <t>CN03</t> (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
Gt9x Link Activity Monitors, supplied by ActiGraph llc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gt9x link activity monitors/product/ActiGraph llc
Average 90 stars, based on 1 article reviews
gt9x link activity monitors - by Bioz Stars, 2026-03
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accelerometer gt3x+ physical activity log  (ActiGraph llc)
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ActiGraph llc accelerometer gt3x+ physical activity log
Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with <t>CN03</t> (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
Accelerometer Gt3x+ Physical Activity Log, supplied by ActiGraph llc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/accelerometer gt3x+ physical activity log/product/ActiGraph llc
Average 90 stars, based on 1 article reviews
accelerometer gt3x+ physical activity log - by Bioz Stars, 2026-03
90/100 stars
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q active hf-x mass spectrometry platform  (Thermo Fisher)
90
Thermo Fisher q active hf-x mass spectrometry platform
Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with <t>CN03</t> (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
Q Active Hf X Mass Spectrometry Platform, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/q active hf-x mass spectrometry platform/product/Thermo Fisher
Average 90 stars, based on 1 article reviews
q active hf-x mass spectrometry platform - by Bioz Stars, 2026-03
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gt9x link wireless activity monitor  (ActiGraph llc)
90
ActiGraph llc gt9x link wireless activity monitor
Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with <t>CN03</t> (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
Gt9x Link Wireless Activity Monitor, supplied by ActiGraph llc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gt9x link wireless activity monitor/product/ActiGraph llc
Average 90 stars, based on 1 article reviews
gt9x link wireless activity monitor - by Bioz Stars, 2026-03
90/100 stars
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Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with CN03 (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.

Journal: Bioactive Materials

Article Title: Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores

doi: 10.1016/j.bioactmat.2026.02.005

Figure Lengend Snippet: Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with CN03 (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.

Article Snippet: Y27632 (13624, Cell Signaling Technology, Inc.) was supplemented to the medium at a concentration of 10 μM, CN03 (Rho Activator II, Cytoskeleton, Inc.) was used at a concentration of 5 μg/ml, and PF228 (PZ0117, Sigma-Aldrich) was supplemented at a concentration of 100 μM.

Techniques: Control, Microscopy, Plasmid Preparation, MANN-WHITNEY